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The group currently consists of Gary Barlow, Howard Donald and Mark Owen. The original line-up also featured Jason Orange and Robbie Williams. Barlow acts as the group's lead singer and primary songwriter, with Owen and Williams initially providing backing vocals and Donald and Orange serving primarily as dancers. APA citation guidelines. APA Style is widely used by students, researchers, and professionals in the social and behavioral sciences. The Scribbr APA Citation Generator automatically generates accurate references and in-text citations for free. Certain USCIS field offices and asylum offices resumed non-emergency face-to-face services to the public on June 4. We have enacted precautions to prevent the spread of the coronavirus (COVID-19) in reopened facilities. You may not enter a USCIS facility if you: Have any symptoms of COVID-19 ... The content currently in English is the official and accurate source for the program information and services DMV provides. Any discrepancies or differences created in the translation are not binding and have no legal effect for compliance or enforcement purposes. If any questions arise related to the information contained in the translated ... Currently we offer walk-up testing at a limited number of community testing sites for patients who don't drive. Check the list to find one open near you. Appointments are also required for these sites. And please remember, when you arrive for testing, you must wear a face covering for the safety of all patients and providers; please only remove ... Currently, CITAS is developing a geographic information system (GIS) containing several cartographic layers and many spatio-temporally referenced attributes. This historical GIS will cover changes over the past 1,250 years in China. If your local office is not listed, there are currently no available appointments. Please select the next closest office to review eligible appointment dates. If you are having difficulty scheduling an appointment on a preferred day, please know all DL offices do have a limited number of same-day appointments available on a first-come, first ...

u/Outhouse_Decorator: COVID-19 Info Page - Updates

2020.05.25 02:16 roro-xpostbot u/Outhouse_Decorator: COVID-19 Info Page - Updates

Salut din nou /Romania!
A trecut ceva timp de la post-ul initial ( https://old.reddit.com/Romania/comments/fw4etcovid19_info_page/ ) , ceea ce inseamna ca multe articole si rezultate au fost publicate intre timp. Am adaugat majoritatea acestora in tabelul din Info page ( http://moitessier-group.mcgill.ca/covid19/covid.php ) dar m-am gandit ca poate ar fi util sa fac un scurt rezumat al celor mai importate stiri:

Medicamente

  1. Trei medicamente au primit din partea Food and Drug Administration (FDA) autorizatie pentru a fi oferite pacientilor cu COVID-19: hydroxychloroquine/chloroquine, remdesivir si un medicament pentru a seda pacientii ce necesita ventilatie mecanica
  2. Intr-un articol publicat acum 2 zile in publicatia The Lancet ( https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31180-6/fulltext31180-6/fulltext) ) , un studiu pe 96000 de pacienti arata ca tratamentul cu hydroxychloroquine/chloroquine nu aduce absolut niciun beneficiu pacientilor cu COVID-19. Mai mult, efecte secundare extrem de periculoase (in special aritmii) au fost observate la majoritatea pacientilor.
  3. Intr-un articol publicat acum 2 zile in publicatia The New England Journal of Medicine ( https://www.nejm.org/doi/full/10.1056/NEJMoa2007764 ) rezultatele arata ca remdesivir e superior fata de placebo cand vine vorba de de a petrece mai putine zile in spital (11 fata de 15). In plus, mortalitatea masurata la 14 zile dupa administrarea tratamentului (sau a unui placebo) arata ca pacientii ce au primit remdesivir mor in medie cu 4% mai putin. Foarte important: remdesivir e util DOAR daca e administrat la pacientii cu varianta usoara/medie de COVID-19. Pacientii cu stadii avansate de COVID-19 nu beneficiaza de rezultatele aratate de remdesivir in pacientii cu boala usoara/medie. Principalul motiv este reprezentat de impactul virusului asupra organismului si a replicarii foarte rapide a virusului in acest stadiu.
  4. Multe alte medicamente: ivermectin, lopinaviritonavir, baricitinib, famotidine, favipiravir - se afla in diferite stadii ale studiilor clinice. Rezultate preliminare sunt asteptate in urmatoarele 2-3 luni.

Vaccinuri

Sunt peste 100 de vaccinuri in dezvoltare. Cele mai importante sunt cum urmeaza:
  1. mRNA-1273 dezvoltat de Moderna Therapeutics: faza I a studiilor clinice arata ca anticorpi au fost generati in toti pacientii (45 pacienti sanatosi intre 18-55 ani) carora le a fost administrat vaccinul. Mai mult, rezultatele arata ca vaccinul este tolerat excelent de pacienti, cu efecte secundare minore. Motive de ingrijorare: mai multi cercetatori, in frunte cu John Rose (Yale University) si Anna Durbin (Johns Hopkins University) sunt sceptici cu privire la rezultatele prezentate de Moderna, in special pentru ca rezultatele nu au fost publicate intr-un jurnal peer-reviewed iar metodele nu au fost publicate nicaieri.
  2. ChAdOx1 nCoV-19 dezvoltat de Universitatea Oxford in parteneriat cu AstraZeneca: rezultatele studiilor clinice initiale arata ca vaccinul a protejat 6 maimute de SARS-CoV-2. Faza I a studiilor clinice a fost finalizata pentru peste 1000 de pacienti, cu rezultatele preliminare aflate in curs de publicare. Fazele II si III sunt in prezent in proces de recrutare de participanti.
  3. INO-4800 dezvoltat de Inovio Pharmaceuticals: faza I a studiilor clinice este in desfasurare. 40 de pacienti au primit prima doza iar rezultatele preliminare sunt asteptate in iunie. O data ce rezultatele sunt procesate si (daca sunt) incurajatoare fazele II/III vor incepe in aceasta vara.
Legat de vaccinuri: consensul este ca un vaccin va fi disponibil abia in urmatoarele 12-18 luni (in cel mai optimist caz):
Dr. Emily Erbelding, an infectious disease expert at NIAID -- which is part of the National Institutes of Health -- said the typical vaccine takes between eight and 10 years to develop. While she is careful not to contradict her boss's timeline -- although she did say "18 months would be about as fast as I think we can go" -- she acknowledged that the accelerated pace will involve "not looking at all the data." - https://www.cnn.com/2020/03/31/us/coronavirus-vaccine-timetable-concerns-experts-invs/index.html
Principalul motiv este legat de necesitatea de a urmari raspunsul imun pe o perioada indelungata, pentru a fi siguri ca nu exista efecte adverse. Cel mai probabil un medicament va ajunge pe piata mai repede decat un vaccin, dar deocamdata, pentru a cita un clasic in viata, "urmaresc cu ingrijorare" situatia :)
Pentru a fi la curent cu ce se intampla in cercetare, recomand cu caldura : https://www.nature.com/articles/d41586-020-00502-w ( Nature wades through the literature on the new coronavirus — and summarizes key papers as they appear. )
In incheiere, va doresc tuturor o saptamana placuta si fara evenimente neprevazute!
submitted by roro-xpostbot to omania [link] [comments]


2020.05.24 19:24 Outhouse_Decorator COVID-19 Info Page - Updates

Salut din nou /Romania!
A trecut ceva timp de la post-ul initial ( https://old.reddit.com/Romania/comments/fw4etcovid19_info_page/ ) , ceea ce inseamna ca multe articole si rezultate au fost publicate intre timp. Am adaugat majoritatea acestora in tabelul din Info page ( http://moitessier-group.mcgill.ca/covid19/covid.php ) dar m-am gandit ca poate ar fi util sa fac un scurt rezumat al celor mai importate stiri:

Medicamente

  1. Trei medicamente au primit din partea Food and Drug Administration (FDA) autorizatie pentru a fi oferite pacientilor cu COVID-19: hydroxychloroquine/chloroquine, remdesivir si un medicament pentru a seda pacientii ce necesita ventilatie mecanica
  2. Intr-un articol publicat acum 2 zile in publicatia The Lancet ( https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31180-6/fulltext31180-6/fulltext) ) , un studiu pe 96000 de pacienti arata ca tratamentul cu hydroxychloroquine/chloroquine nu aduce absolut niciun beneficiu pacientilor cu COVID-19. Mai mult, efecte secundare extrem de periculoase (in special aritmii) au fost observate la majoritatea pacientilor.
  3. Intr-un articol publicat acum 2 zile in publicatia The New England Journal of Medicine ( https://www.nejm.org/doi/full/10.1056/NEJMoa2007764 ) rezultatele arata ca remdesivir e superior fata de placebo cand vine vorba de de a petrece mai putine zile in spital (11 fata de 15). In plus, mortalitatea masurata la 14 zile dupa administrarea tratamentului (sau a unui placebo) arata ca pacientii ce au primit remdesivir mor in medie cu 4.8 puncte procentuale mai putin. Foarte important: remdesivir e util DOAR daca e administrat la pacientii cu varianta usoara/medie de COVID-19. Pacientii cu stadii avansate de COVID-19 nu beneficiaza de rezultatele aratate de remdesivir in pacientii cu boala usoara/medie. Principalul motiv este reprezentat de impactul virusului asupra organismului si a replicarii foarte rapide a virusului in acest stadiu.
  4. Multe alte medicamente: ivermectin, lopinaviritonavir, baricitinib, famotidine, favipiravir - se afla in diferite stadii ale studiilor clinice. Rezultate preliminare sunt asteptate in urmatoarele 2-3 luni.

Vaccinuri

Sunt peste 100 de vaccinuri in dezvoltare. Cele mai importante sunt cum urmeaza:
  1. mRNA-1273 dezvoltat de Moderna Therapeutics: faza I a studiilor clinice arata ca anticorpi au fost generati in toti pacientii (45 pacienti sanatosi intre 18-55 ani) carora le a fost administrat vaccinul. Mai mult, rezultatele arata ca vaccinul este tolerat excelent de pacienti, cu efecte secundare minore. Motive de ingrijorare: mai multi cercetatori, in frunte cu John Rose (Yale University) si Anna Durbin (Johns Hopkins University) sunt sceptici cu privire la rezultatele prezentate de Moderna, in special pentru ca rezultatele nu au fost publicate intr-un jurnal peer-reviewed iar metodele nu au fost publicate nicaieri.
  2. ChAdOx1 nCoV-19 dezvoltat de Universitatea Oxford in parteneriat cu AstraZeneca: rezultatele studiilor clinice initiale arata ca vaccinul a protejat 6 maimute de SARS-CoV-2. Faza I a studiilor clinice a fost finalizata pentru peste 1000 de pacienti, cu rezultatele preliminare aflate in curs de publicare. Fazele II si III sunt in prezent in proces de recrutare de participanti.
  3. INO-4800 dezvoltat de Inovio Pharmaceuticals: faza I a studiilor clinice este in desfasurare. 40 de pacienti au primit prima doza iar rezultatele preliminare sunt asteptate in iunie. O data ce rezultatele sunt procesate si (daca sunt) incurajatoare fazele II/III vor incepe in aceasta vara.
Legat de vaccinuri: consensul este ca un vaccin va fi disponibil abia in urmatoarele 12-18 luni (in cel mai optimist caz):
Dr. Emily Erbelding, an infectious disease expert at NIAID -- which is part of the National Institutes of Health -- said the typical vaccine takes between eight and 10 years to develop. While she is careful not to contradict her boss's timeline -- although she did say "18 months would be about as fast as I think we can go" -- she acknowledged that the accelerated pace will involve "not looking at all the data." - https://www.cnn.com/2020/03/31/us/coronavirus-vaccine-timetable-concerns-experts-invs/index.html
Principalul motiv este legat de necesitatea de a urmari raspunsul imun pe o perioada indelungata, pentru a fi siguri ca nu exista efecte adverse. Cel mai probabil un medicament va ajunge pe piata mai repede decat un vaccin, dar deocamdata, pentru a cita un clasic in viata, "urmaresc cu ingrijorare" situatia :)
Pentru a fi la curent cu ce se intampla in cercetare, recomand cu caldura : https://www.nature.com/articles/d41586-020-00502-w ( Nature wades through the literature on the new coronavirus — and summarizes key papers as they appear. )
In incheiere, va doresc tuturor o saptamana placuta si fara evenimente neprevazute!
submitted by Outhouse_Decorator to Romania [link] [comments]


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